Scientists have developed a nanomotor that uses bowl-shaped mesoporous polydopamine (PDA) nanoparticles loaded with Fe(II) ions and BNN6, a thermally sensitive NO donor. The nanoparticles were then coated with a fragment of MCF-7 breast cancer cell membrane.
Key Details
- The PDA nanoparticles are biocompatible and bowl-shaped.
- Fe(II) ions act as a Fenton catalyst.
- BNN6 is a thermally sensitive nitric oxide (NO) donor.
- The resulting PFB nanoparticles are cloaked with MCF-7 cancer cell membrane fragments.
- The membrane camouflage serves two functions: evading immune clearance and providing homologous targeting to MCF-7 cells.
"The membrane camouflage helps the nanomotor evade immune clearance and provides homologous targeting, as the membrane proteins recognize and bind specifically to the same type of cancer cells."
— Professor Hu